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Recurrent Miscarriage and Implantation Failure: Causes and What Can Help

Op. Dr. Ali İhsan Gönenç
Written & medically reviewed by: Op. Dr. Ali İhsan Gönenç
Published: 2026-07-13 · Updated: 2026-07-13
Couple discussing recurrent miscarriage and implantation failure with a specialist

Experiencing repeated pregnancy loss or embryos that do not implant is emotionally difficult — but in many cases, careful investigation can identify contributing factors and guide an effective plan.

What is recurrent miscarriage?

Recurrent miscarriage generally refers to two or more consecutive pregnancy losses. Recurrent implantation failure describes repeated IVF cycles in which good-quality embryos are transferred but pregnancy does not occur.

What causes recurrent miscarriage and implantation failure?

  • Chromosomal factors in the embryo, often related to age
  • Uterine factors such as polyps, fibroids or adhesions
  • Hormonal or thyroid problems
  • Immune or blood-clotting disorders in some cases

Often it is a combination of factors, and in some couples no single cause is found.

How is it investigated?

Investigation may include a detailed review of the embryos and cycles, hormonal tests, an assessment of the uterine cavity, and, in some cases, immune or clotting tests. The aim is to identify anything treatable.

Can IVF help with recurrent miscarriage?

Yes, in the right situations. Where chromosomal issues are a concern, genetic testing (PGT) during IVF can help select a healthy embryo and reduce miscarriage risk. Uterine problems can often be treated before transfer.

What can improve the chance next time?

After repeated loss or failure, the plan is re-evaluated and personalized — addressing uterine, hormonal and embryo-related factors. Many couples go on to have a successful pregnancy after the right adjustments. Read more about why IVF can fail.

When to seek specialist help

If you have had two or more losses, or repeated unsuccessful IVF transfers, a focused evaluation is recommended. Timely, individualized assessment offers the best chance of identifying what can be improved.

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FAQ

Frequently Asked Questions

Clear answers to the most common questions.

Recurrent miscarriage generally means two or more consecutive pregnancy losses. It warrants a focused evaluation to look for treatable contributing factors.

It describes repeated IVF cycles in which good-quality embryos are transferred but pregnancy does not occur. The causes are investigated to update the treatment plan.

Causes can include embryo chromosomal factors (often age-related), uterine problems, hormonal or thyroid issues, and in some cases immune or clotting disorders. Often it is a combination.

Yes, in suitable cases. Where chromosomal issues are a concern, genetic testing (PGT) during IVF can help select a healthy embryo and reduce miscarriage risk.

Investigation may include reviewing embryos and cycles, hormonal tests, assessing the uterine cavity, and sometimes immune or clotting tests. The aim is to find anything treatable.

Yes. With age, the chance of embryo chromosomal errors rises, which increases miscarriage risk. This is why age is an important part of the assessment.

Yes. Polyps, fibroids or adhesions affecting the uterine cavity can hinder implantation and can often be treated before transfer.

Some immune or blood-clotting disorders can contribute to recurrent loss and are investigated in appropriate cases. Treatment is added when a specific issue is identified.

Yes. Many couples go on to have a successful pregnancy after the causes are reviewed and the plan is personalized. One or more losses do not mean future attempts will fail.

If you have had two or more losses or repeated unsuccessful IVF transfers, a focused evaluation is recommended. Timely assessment offers the best chance of finding what can be improved.